Combined glutathione S transferase M1/T1 null genotypes is associated with type 2 Diabetes mellitus
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چکیده
منابع مشابه
Combined glutathione S transferase M1/T1 null genotypes is associated with type 2 diabetes mellitus
BACKGROUND Due to new genetic insights, a considerably large number of genes and polymorphic gene variants are screened and linked with the complex pathogenesis of type 2 diabetes (DM). Our study aimed to investigate the association between the two isoforms of the glutathione S-transferase genes (Glutathione S transferase isoemzyme type M1- GSTM1 and Glutathione S transferase isoemzyme type T1-...
متن کاملInfluence of glutathione S-transferase polymorphisms on type-2 diabetes mellitus risk.
Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing type-2 diabetes mellitus and on glycemic control. We also investigated the effects of smoking combined with these polymorphisms on type-2 diabetes mellitus risk. We enrolled 100 type-2 diabetes mellitus patients and 100 health...
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BACKGROUND Due to the activity of GSTs in the detoxification of oxidative stress products, deletion polymorphisms of GSTM1 and GSTT1 may contribute to susceptibility to T2DM, since B-cells express very low levels of antioxidant enzymes. Recently, some studies have shown an association between GSTM1-null/GSTT1-null genotypes and an increased susceptibility to T2DM. A relationship between these p...
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BACKGROUND Glutathione S-transferases (GSTs) modulate oxidative stress, and variation in GST genes has been associated with cardiovascular disease risk. We prospectively determined smoking-related cardiovascular morbidity by GST genotype in a large cohort of individuals with type 2 diabetes using a population-based diabetes research database (DARTS). METHODS AND RESULTS We performed a cohort ...
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ژورنال
عنوان ژورنال: Medicine and Pharmacy Reports
سال: 2015
ISSN: 2668-0572,2602-0807
DOI: 10.15386/cjmed-436